Vice President, Translational Medicine & Clinical Biomarkers

Nurix Therapeutics is seeking an accomplished scientific leader to serve as Vice President, Translational Medicine & Clinical Biomarkers in Brisbane, California. In this full-time executive role, you will architect and lead the translational medicine and clinical biomarker strategy across our oncology and immunology pipeline, making critical portfolio decisions from target engagement through late-stage clinical development.

About the Role

Reporting to the Chief Scientific Officer, you will build and scale a high-performing translational team, manage external partnerships, and serve as a scientific authority representing Nurix in translational medicine forums. This is a senior executive position for a builder—someone who has led translational functions through significant clinical milestones and can define what precision medicine strategy looks like for novel targeted protein degradation therapies.

Responsibilities

• Develop and champion the enterprise translational medicine strategy, integrating discovery and clinical insights to guide portfolio prioritization and investment decisions
• Design predictive biomarker frameworks and translational plans supporting indication selection and patient enrichment for novel degrader therapeutics
• Oversee complete biomarker program lifecycles from preclinical assay development through clinical validation and regulatory reporting, ensuring scientific rigor and defensibility
• Direct pharmacodynamic, predictive, safety, and prognostic biomarker strategy design with measurable decision gates at clinical inflection points
• Integrate cutting-edge translational platforms—ctDNA/RNA analysis, single-cell sequencing, spatial transcriptomics, computational pathology—into precision medicine initiatives
• Lead synthesis and interpretation of clinical biomarker data; translate complex findings for clinical, executive, and regulatory audiences
• Provide scientific leadership for clinical protocols, regulatory submissions, investigator materials, and FDA/EMA interactions
• Partner with Clinical Pharmacology on integrated PK/PD analysis and mechanism-based endpoint selection
• Oversee companion diagnostic strategy, partner evaluation, and regulatory co-development planning
• Build and govern CRO and central laboratory partnerships with accountability for scientific quality and contractual delivery
• Establish translational medicine operating infrastructure, quality standards, and resource management aligned with pipeline milestones

What You Bring

• Ph.D. in Immunology, Oncology, Biochemistry, Cell Biology, or related life sciences (MD/Ph.D. strongly preferred)
• 15+ years of translational medicine or clinical biomarker leadership in pharma/biotech with substantial oncology experience
• 10+ years in senior scientific leadership roles (Sr. Director level or above) with direct team management and budget responsibility
• Proven track record leading translational programs from IND through Phase II proof-of-concept, including first-in-human study design
• Substantial experience with Phase III biomarker programs and regulatory submissions (FDA/EMA)
• Expertise in translational biomarker strategy: target engagement, pharmacodynamic, predictive, prognostic, and safety biomarkers
• Proficiency with quantitative and multiplex biomarker technologies including flow cytometry, ELISA, IHC/immunofluorescence, NGS, ctDNA/cfDNA, and digital pathology
• Understanding of regulatory frameworks governing exploratory biomarkers and companion diagnostic development
• Strong publication record and active engagement in translational medicine scientific communities
• Demonstrated ability selecting, governing, and partnering with CROs and laboratory service providers
• Familiarity with bioinformatic and multi-omic data integration approaches; ability to collaborate with data science teams
• Preferred: Direct experience with targeted protein degradation therapeutics (PROTACs, molecular glues) and associated translational challenges
• Preferred: Expertise spanning both oncology and immunology/inflammatory disease therapeutic areas
• Preferred: Experience building translational medicine or clinical biomarker functions from early stage, including infrastructure and team design
• Preferred: Familiarity with AI-driven and computational approaches in translational science and biomarker discovery

Why Join Nurix

Nurix Therapeutics pioneers targeted protein degradation as a transformative therapeutic modality for oncology and inflammatory disease. Powered by AI-integrated discovery and industry-leading ligase expertise, we are translating degrader science into clinical advancement. This role offers the rare opportunity to define translational excellence and precision medicine strategy for the next generation of medicines. You'll partner with accomplished R&D, clinical, regulatory, and data science leaders who value scientific rigor, intellectual curiosity, and patient-centered innovation—and who recognize that building world-class science and building talented teams are equally important pursuits.

How to Apply

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