- Company: Vrtx
- Location: Boston, MA
- Full Time
- Boston, MA
- Apply on company site
Vrtx at a glance
vrtx.comSEC filings mentioning "Vrtx": 2,574 — search EDGAR
VRTX (Versatile Real-Time Executive) is a real-time operating system once marketed by Mentor Graphics for board-level embedded systems and SoCs; it has been superseded by Nucleus RTOS. Public headlines tied to the VRTX ticker also reference biotech deal and stock coverage (e.g. Yahoo Finance).
163 Wikipedia views in June 2026 — a rough gauge of public visibility.
Source: Wikipedia
Vrtx is seeking a Principal Statistical Programmer for a full-time opportunity based in Boston, MA. This senior-level statistical programming position invites experienced professionals to drive high-impact analysis deliverables while advancing their career with a dedicated team in the Boston area.
About the Role
As Principal Statistical Programmer at Vrtx in Boston, MA, you will serve as a technical leader guiding complex programming initiatives that transform clinical and research data into reliable insights. The Principal Statistical Programmer role centers on ownership of end-to-end programming strategy, quality oversight, and mentorship within a collaborative full-time setting. Candidates searching for Principal Statistical Programmer jobs in Boston, MA or Principal Statistical Programmer near me will find this position aligns with the advanced expertise and leadership trajectory they seek while remaining fully on-site in Boston.
Core Duties
- Direct the design, development, and validation of analysis datasets, tables, listings, and figures for clinical study reports and exploratory analyses
- Establish and enforce programming standards, macros, and reusable code libraries that align with industry best practices
- Ensure all statistical programming output meets regulatory submission readiness, including CDISC-compliant structures such as SDTM and ADaM
- Mentor and review work of junior and mid-level statistical programmers to elevate team capability and consistency
- Partner closely with biostatisticians, data managers, and cross-functional stakeholders to translate analysis plans into accurate, efficient code
- Troubleshoot complex data issues, optimize runtime performance, and maintain version-controlled repositories throughout the project lifecycle
- Contribute to continuous improvement of programming processes and documentation practices for Boston-based Vrtx projects
Qualifications
- Advanced proficiency in statistical programming languages, particularly SAS, with demonstrated ability to produce production-grade, validated code
- Deep working knowledge of CDISC standards (SDTM, ADaM), define.xml, and other regulatory submission components
- Proven track record leading statistical programming activities across multiple studies or programs as a Principal Statistical Programmer or equivalent senior role
- Strong understanding of clinical trial data structures, protocols, statistical analysis plans, and reporting requirements
- Excellent problem-solving, communication, and stakeholder collaboration skills suited to a full-time on-site environment in Boston, MA
- Bachelor’s or advanced degree in statistics, biostatistics, computer science, mathematics, or a closely related quantitative field
- Familiarity with additional tools such as R, Python, or SQL as complementary technologies is valued
About the Company
Vrtx is hiring for this role and offers a supportive team environment for professionals pursuing Principal Statistical Programmer careers in Boston, MA.
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To apply for this job please visit vrtx.wd501.myworkdayjobs.com.
Explore Vrtx online
What people say about Vrtx
- Next Week's Bloodbath At IBM Won't Fix The Real Problem
- The Orange Box: Cloud for the Free Man
- Use One Big Server (2022)
- Stem cells reverse woman’s diabetes
Recent news
- symbol__ Stock Quote Price and Forecast - CNN
- Vertex (VRTX) Stock May Be 36% Undervalued Following Its $10b Deal - Yahoo Finance
- (VRTX) Risk Channels and Responsive Allocation - Stock Traders Daily
- Weekly Buzz: JNJ, VERA Get FDA Nod; VRTX Snaps Up CRNX; MSLE Aces DMD Trial; IONS Misses Key Goal - RTTNews
- Vertex to buy Crinetics for $10 billion in rare-diseases push - Reuters
Aggregated from public discussions and news; opinions are the authors’ own.
Working in Boston, Suffolk County
Weather right now in Boston, Suffolk County: checking… · Local time: · Air quality: · Daylight: · UV index: · Wind: · Pollen:
Boston is Massachusetts’s capital and New England’s cultural and financial hub—about 48.4 sq mi and ~675,647 residents (2020). On-site work is in this dense Northeast metro.
Massachusetts, officially the Commonwealth of Massachusetts, is a state in the New England region of the Northeastern United States. It borders the Atlantic Ocean and the Gulf of Maine to its east, Connecticut and Rhode Island to its south, New Hampshire and Vermont to its north, and New York to its west. Massachusetts is the seventh-smallest state by land area. With an estimated population of ove
🇺🇸 Relocation safety for US: Exercise Normal Caution — via Warnely, CC BY 4.0
National unemployment rate in US: 4.2% — via World Bank
Private-sector wage growth (year over year): 3.3% — via FRED
National quits rate: 1.9% — via FRED (BLS JOLTS)
Weekly initial unemployment claims: 208,000 — via FRED
GDP per capita in US: $90,027 — via World Bank
Consumer price inflation in US: 2.9% (annual) — via World Bank
Real GDP growth in US: 2.2% (annual) — via World Bank
Average hours worked per year in US: 1,800 — via OECD
Cost of living in Massachusetts: 5.8% above the national average — via BEA
Minimum wage in Massachusetts: $15.00/hr — via FRED
Home prices in Massachusetts (year over year): +4.2% — via FRED
Median household income in Suffolk County: $92,859 — via US Census ACS / Data USA
Most recent FEMA-declared disaster in Suffolk County: Hurricane Lee (Hurricane), Sep 2023 — via FEMA
Average commute time in Suffolk County: 31 min — via US Census ACS / Data USA
Most common commute in Suffolk County: Drove Alone (35%) — via US Census ACS / Data USA
Households with home internet in Suffolk County: 92% — via US Census ACS / Data USA
Nearby history: Ames Building, listed 1974 (30m away) — via National Register of Historic Places
Typical climate: average high 60°F / low 41°F year-round (summers around 80°F, winters around 23°F) — via NOAA 1991-2020 Normals
Walkability: Most walkable (18.3/20) — via EPA National Walkability Index
Typical rent nearby: $2,476/mo (1BR) · $2,941/mo (2BR) — via HUD Fair Market Rents
- Elevation 29m (95 ft)
Source: Wikipedia (state)
About this role & career path
Principal level typically means leading standards, mentoring programmers, and owning critical study or product analyses beyond a senior IC scope. Growth often moves toward stats leadership or cross-functional science roles.
Traits that fit this role
- Achievement Orientation
- Intellectual Curiosity
- Cautiousness
- Integrity
- Attention to Detail
Source: O*NET Work Styles (Distinctiveness Rank).
Typical preparation needed: Job Zone 5: Extensive Preparation Needed. Most of these occupations require graduate school -- for example, a master's degree, and some require a Ph.D., M.D., or J.D. — via O*NET
Industry news
- Want a software engineering job? You'll need more than coding skills in the AI era. - Business Insider
- ‘AI code apocalypse’ hasn’t hit engineers as hard as the industry may think - IT Brew
- AI tools have sparked a coding revolution. Software engineers are figuring out what comes next. - Business Insider
Source: O*NET (public-domain bulk data)
Salary & compensation
Workers in Computer & Mathematical occupations earn a national median of $98,769 — via US Census ACS / Data USA
Build the skills for this role
Build programming depth with free paths:
- freeCodeCamp — Full Stack (free)
- Saylor CS courses (free)
- CS50 (free to learn)
- Microsoft Learn (free to learn)
Free & low-cost learning resources
- freeCodeCamp — Full Stack curriculum (free)
- Saylor Academy — Computer Science courses (free)
- CS50 (Harvard, via edX) (free to learn)
- Microsoft Learn — developer training paths (free to learn)
Be ready on method choice, data QC, and how you present findings. Walk through a complex analysis end-to-end: assumptions, validation, and tables/figures for decision-makers.
Strong fit if you lead statistical programming with rigorous QC and clear reporting, and prefer Boston on-site work over remote.
Job details above are provided by the employer/source. The sections on this page are compiled from public data sources with AI assistance.
Accommodations: if you need a workplace accommodation to apply for or perform this job, see ADA.gov or EEOC.gov for guidance on your rights and how to request one.
Listing facts
- Role Principal Statistical Programmer
- Employer Vrtx
- Location Boston, MA
- Type Full Time
- Posted July 13, 2026
- Apply by 2026-08-12
- Country context US
- Overview Full original description on this page (410 words; rewritten for clarity, not a teaser paste)
Facts above come from this job record on Get A Job.AI — not copied from third-party review sites.
Typical work in Senior Statistical Programmer
Independent occupational context from O*NET (U.S. public-domain labor data). This is about the occupation, not a rewrite of this employer's posting.
- Analyze and interpret statistical data to identify significant differences in relationships among sources of information.
- Evaluate the statistical methods and procedures used to obtain data to ensure validity, applicability, efficiency, and accuracy.
- Report results of statistical analyses, including information in the form of graphs, charts, and tables.
- Determine whether statistical methods are appropriate, based on user needs or research questions of interest.
- Prepare data for processing by organizing information, checking for inaccuracies, and adjusting and weighting the raw data.
- Develop and test experimental designs, sampling techniques, and analytical methods.
Public discussions & open sources
Attributed public threads and profiles — not employee reviews or star ratings.
- Hacker News — Next Week's Bloodbath At IBM Won't Fix The Real Problem
- Hacker News — The Orange Box: Cloud for the Free Man
- Hacker News — Use One Big Server (2022)
- Hacker News — Stem cells reverse woman’s diabetes
Cached public sources (Hacker News, Dev.to, GitHub, etc.).
Employer website
Explore related openings
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Occupation family: Senior Statistical Programmer
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