Principal Statistical Programmer

How to use this kit

Ground every answer in facts on this page and the original listing. We never invent Glassdoor-style reviews or salaries that are not in our data.

Interview prep

Be ready on method choice, data QC, and how you present findings. Walk through a complex analysis end-to-end: assumptions, validation, and tables/figures for decision-makers.

Fit summary

Strong fit if you lead statistical programming with rigorous QC and clear reporting, and prefer Boston on-site work over remote.

Day in the role

As Principal Statistical Programmer at Vrtx in Boston, expect senior ownership of analysis pipelines: validate methods, prepare and weight raw data, run designs/sampling checks, and deliver graphs, tables, and written results for stakeholders—aligned with statistician/programmer tasks.

Skills to emphasize

Build programming depth with free paths:

• freeCodeCamp — Full Stack (free)
• Saylor CS courses (free)
• CS50 (free to learn)
• Microsoft Learn (free to learn)

FAQ from this listing

Is this role remote?

No—listing marks remote as off; expect Boston, MA presence.

What does the day emphasize?

Analysis validity, data prep, and communicating results with charts and tables.

Where can I skill up cheaply?

Use freeCodeCamp, Saylor, CS50, and Microsoft Learn (free or free to learn) from the cert list.

Occupation tasks (O*NET)

Public-domain labor data — prepare examples for 2–3 of these.

• Analyze and interpret statistical data to identify significant differences in relationships among sources of information.
• Evaluate the statistical methods and procedures used to obtain data to ensure validity, applicability, efficiency, and accuracy.
• Report results of statistical analyses, including information in the form of graphs, charts, and tables.
• Determine whether statistical methods are appropriate, based on user needs or research questions of interest.
• Prepare data for processing by organizing information, checking for inaccuracies, and adjusting and weighting the raw data.
• Develop and test experimental designs, sampling techniques, and analytical methods.
• Identify relationships and trends in data, as well as any factors that could affect the results of research.
• Present statistical and nonstatistical results, using charts, bullets, and graphs, in meetings or conferences to audiences such as clients, peers, and students.

O*NET source

Company facts (cached)

Website: vrtx.com

Versatile Real-Time Executive (VRTX) is a real-time operating system (RTOS) developed and marketed by the company Mentor Graphics. VRTX is suitable for both traditional board-based embedded systems and system on a chip (SoC) architectures. It has been superseded by the Nucleus RTOS.

Public cache only — not an employee review.

Role overview (listing rewrite)

Vrtx is seeking a Principal Statistical Programmer for a full-time opportunity based in Boston, MA. This senior-level statistical programming position invites experienced professionals to drive high-impact analysis deliverables while advancing their career with a dedicated team in the Boston area. About the Role As Principal Statistical Programmer at Vrtx in Boston, MA, you will serve as a technical leader guiding complex programming initiatives that transform clinical and research data into reliable insights. The Principal Statistical Programmer role centers on ownership of end-to-end programming strategy, quality oversight, and mentorship within a collaborative full-time setting. Candidates searching for Principal Statistical Programmer jobs in Boston, MA or Principal Statistical Programmer near me will find this position aligns with the advanced expertise and leadership trajectory they seek while remaining fully on-site in Boston. Core Duties Direct the design, development, and validation of analysis datasets, tables, listings, and figures for clinical study reports and exploratory analyses Establish and enforce programming standards, macros, and reusable code libraries that align with industry best practices Ensure all statistical programming output meets regulatory submission readiness, including CDISC-compliant structures such as SDTM and ADaM Mentor and review work of junior and mid-level statistical programmers to elevate team capability and consistency Partner closely with biostatisticians, data managers, and cross-functional stakeholders to translate analysis plans into accurate, efficient code Troubleshoot complex data issues, optimize runtime performance, and maintain version-controlled repositories throughout the project lifecycle Contribute to continuous improvement of programming processes and documentation practices for Boston-based Vrtx projects Qualifications Advanced proficiency in statistical programming languages, particularly SAS, with demonstrated ability to produce production-grade, validated code Deep working knowledge of CDISC standards (SDTM, ADaM), define.xml, and other regulatory submission components Proven track record leading statistical programming activities across multiple studies or programs as a Principal Statistical Programmer or equivalent senior role Strong understanding of clinical trial data structures, protocols, statistical analysis plans, and reporting requirements Excellent problem-solving, communication, and stakeholder collaboration skills suited to a full-time on-site environment in Boston, MA Bachelor’s or advanced degree in statistics, biostatistics, computer science, mathematics, or a closely related quantitative field Familiarity with additional tools such as…

Full job on Get A Job.AI

Questions to ask them

• What does success look like in the first 90 days for this role?
• How is the team structured, and who would I work with most?
• What tools and systems does this role use daily?
• Is the work primarily based in Boston, MA, hybrid, or fully remote?