Senior/Executive Director, Business Operations

Join BridgeBio Pharma as Senior/Executive Director, Business Operations in a full-time capacity at our San Francisco headquarters (1800 Owens). This pivotal role shapes our Encaleret program's path to commercial success through strategic planning and cross-functional leadership.

The Opportunity

This is a compelling opportunity to drive business transformation within a pioneering biotech organization. You will architect strategic initiatives that directly advance our Encaleret program toward commercial success, combining financial acumen with leadership across multiple functional teams. Your impact spans market readiness planning, financial modeling, investor communications, and corporate partnerships—all designed to bring innovative therapies to patients with unmet medical needs.

Day-to-Day Responsibilities

• Develop and communicate comprehensive strategic plans that guide resource allocation and organizational priorities for the Encaleret program
• Build financial models, including discounted cash flow analyses, alongside market research on competitive therapeutics and patient epidemiology to inform program strategy
• Design and present executive-level materials for board presentations, investor meetings, and internal strategy sessions, synthesizing complex technical and commercial data into clear, actionable insights
• Work closely with R&D, regulatory affairs, finance, commercial, and operations teams to ensure integrated strategy development and execution
• Own budget planning and long-term product lifecycle management to support both near-term launch readiness and sustained commercial performance
• Research pricing strategies and reimbursement landscapes in collaboration with the commercial team to optimize market access
• Lead cross-functional initiatives related to product lifecycle planning, market expansion, and operational efficiency

What We're Looking For

• Master's degree or equivalent (MBA, MD, or Ph.D.) preferred
• 2–5 years of professional experience in management consulting (with life sciences background preferred), venture capital, investment banking, equity research, post-Series A funding, or operational roles within therapeutics organizations
• Strong foundation in financial modeling, particularly discounted cash flow (DCF) analysis
• Deep understanding of the drug development lifecycle from discovery through commercial execution, including the biotech operating model and competitive landscape
• Prior involvement in new product commercialization programs (a significant plus)
• Demonstrated scientific reasoning ability combined with exceptional communication and presentation skills
• Commitment to improving patient outcomes and advancing rare disease therapeutics
• Ability to synthesize technical and commercial information for diverse audiences—from scientific experts to investment professionals

About the Company

Since 2015, BridgeBio Pharma has reimagined drug discovery and development through a distinctive financial model that de-risks innovation. By consolidating promising early-stage research from academic centers under unified funding, we empower small, expert teams to move science forward without conventional constraints. Our mission centers on bridging groundbreaking discoveries to rare disease patients with unmet needs, working at speed to deliver transformative medicines. We foster a culture that celebrates curiosity, rigorous experimentation, and thoughtful technology adoption—including AI—to enhance decision-making and accelerate impact.

Next Steps

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