Senior Medical Director, Early Clinical Development

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BioMarin Pharmaceutical is seeking a Senior Medical Director, Early Clinical Development to help advance breakthrough therapies for rare, genetically defined diseases across the United States. This is a pivotal leadership opportunity to shape the early-stage clinical strategy behind life-changing medicines.

About the Role

As Senior Medical Director, Early Clinical Development at BioMarin Pharmaceutical, you will provide clinical and scientific leadership during the earliest phases of drug development. Based in the US, this full-time, on-site position places you at the heart of translating cutting-edge science into first-in-human studies that bring hope to patients living with rare conditions.

Key Responsibilities

• Direct the medical and scientific strategy for early-phase (Phase 1 and 2) clinical programs.
• Serve as the clinical lead on cross-functional development teams, guiding study design and protocol development.
• Oversee the safety, integrity, and scientific rigor of ongoing early clinical trials.
• Interpret emerging clinical data to inform go/no-go decisions and program direction.
• Partner with regulatory, research, and commercial colleagues to progress candidates through the development pipeline.
• Contribute clinical expertise to interactions with health authorities, investigators, and key external stakeholders.

Qualifications

• Medical degree (MD or equivalent) with relevant clinical and therapeutic experience.
• Substantial background in early clinical development within the biotechnology or pharmaceutical industry.
• Strong command of clinical trial design, drug safety, and the regulatory landscape.
• Proven ability to lead multidisciplinary teams and drive complex programs forward.
• Excellent scientific judgment, communication, and collaborative skills.

About BioMarin Pharmaceutical

Founded in 1997, BioMarin is a global leader in rare disease biotechnology, devoted to developing medicines that make a meaningful difference in patients' lives. The company has built a respected portfolio of therapies for genetically defined conditions, including treatments for achondroplasia — the most common form of dwarfism — and PKU. Driven by science and a deep sense of purpose, BioMarin's teams pursue innovative treatments where few options previously existed.

How to Apply

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