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Be ready to walk through complex PK case studies (nonlinearity, special populations, drug–drug interactions), how you set exposure targets, and how you resolve conflicting data with clinical teams. Expect questions on prioritization across multiple therapeutic programs.
Strong fit if you are a senior PK/clinical pharmacology scientist who thrives in large-pharma matrix teams and can own therapeutic-area PK strategy end to end in Cambridge-based R&D.
As Principal Scientist I/II in PK Sciences Therapeutic Areas at Novartis, your day centers on pharmacokinetic strategy across programs: interpreting exposure–response and ADME data, advising clinical and discovery teams on dose and study design, reviewing study plans and reports, and aligning therapeutic-area stakeholders on PK/PD risk and next experiments.
No cert family or priced resources were provided. Prioritize advanced PK/PD and clinical pharmacology judgment, regulatory-facing writing, and cross-functional leadership with discovery, clinical, and biostatistics partners.
The listing marks remote as no; plan on on-site or site-based work in the Cambridge area.
The title spans Principal Scientist I or II across PK Sciences therapeutic areas, so level and TA focus may vary by opening.
Novartis AG is headquartered in Basel, Switzerland, with major global R&D and commercial sites, including Cambridge-linked activity for this posting.
Website: novartis.com
Novartis AG is a Swiss multinational pharmaceutical corporation based in Basel, Switzerland. Novartis is one of the largest pharmaceutical companies in the world and was the eighth largest by revenue in 2024.
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Join Novartis as a Principal Scientist I or II, PK Sciences Therapeutic Areas in Cambridge, Henry County. This full-time position offers the opportunity to drive pharmacokinetic research and translational science in support of our most promising therapeutic programs across multiple therapeutic areas. About the Role Novartis is searching for a seasoned Principal Scientist to lead pharmacokinetics (PK) sciences initiatives that bridge translational research and late-stage clinical development. You will shape dosing strategies, optimize drug exposure across patient populations, and translate laboratory findings into clinically meaningful insights that accelerate our path to transformative medicines. What You'll Do Design and execute pharmacokinetic and translational pharmacology studies to inform clinical development strategies Conduct rigorous data analysis and modeling to characterize drug behavior, bioavailability, and exposure-response relationships Collaborate with clinical, regulatory, and development teams to establish dosing rationales and define patient population strategies Lead scientific recommendations and prepare regulatory submissions to support IND applications and clinical trial progress Synthesize complex pharmacological data into clear strategic guidance for cross-functional project teams Mentor junior scientists and contribute to knowledge-sharing within the PK sciences community What We're Looking For PhD or equivalent in pharmacology, pharmacokinetics, toxicology, pharmaceutical sciences, or related discipline 5+ years of professional experience in pharmaceutical PK sciences, clinical pharmacology, or translational research Demonstrated expertise in pharmacokinetic study design, data analysis, and modeling Strong grasp of regulatory pathways and ability to communicate with FDA and other health authorities Proven leadership abilities and track record of contributing to successful program advancement Excellent written and verbal communication skills; ability to influence and collaborate across organizations About Novartis Novartis reimagines medicine to improve and extend lives. Our innovative research, world-class manufacturing, and global reach enable us to deliver breakthrough treatments across therapeutic areas where unmet patient needs remain high. How to Apply Ready to make an impact? Apply through this listing to join our Cambridge team.
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