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Be ready to walk through CMC case studies: how you de-risked formulation or process issues, led tech transfer, and partnered with clinical/regulatory stakeholders. Prepare examples of team leadership, vendor management, and trade-offs under timeline pressure for a Director, Pharmaceutical Development scope at a company like Nurix.
Strong fit if you already lead pharmaceutical development work end-to-end and want on-site Director ownership in Brisbane, CA. Data is thin on culture, compensation, and local context—treat those as open diligence items with the employer.
As Director, Pharmaceutical Development at Nurix in Brisbane, CA, a typical day centers on leading formulation and process-development strategy for pipeline candidates: aligning CMC priorities with discovery and clinical partners, reviewing study designs and data packages, unblocking scale-up or tech-transfer issues, and guiding a cross-functional team through stage-gate decisions. Expect frequent internal reviews, vendor or CDMO check-ins, and documentation that supports regulatory readiness rather than bench work as the primary focus.
Prioritize depth in small-molecule or modality-relevant CMC, late-phase process/formulation development, and cross-functional program leadership. Strengthen regulatory and quality fluency (IND/IMPD-facing packages, change control), CDMO oversight, and people management. No certification resources were provided for this role family.
No. The listing marks remote as 0, so expect on-site work in Brisbane, CA.
Director, Pharmaceutical Development points to leadership of CMC/formulation and process-development strategy rather than a pure discovery science role.
Start with the employer site at nurix.com; no additional verified company dossier was included in the source data.
Website: nurix.com
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Join Nurix Therapeutics as Director of Pharmaceutical Development in our Brisbane, California headquarters, leading the science and strategy behind next-generation small molecule therapies from bench to patient. What This Role Involves As Director of Pharmaceutical Development, you'll spearhead the end-to-end development strategy for oral and topical small molecule drug products. This is a hands-on leadership position that combines technical depth—designing and optimizing formulations for complex compounds—with strategic oversight of vendor partnerships, cross-functional teams, and regulatory submissions. You'll drive programs through all stages: early formulation work, manufacturing scale-up, late-stage clinical supply, and commercial launch. This full-time, on-site role is ideal for a seasoned pharmaceutical scientist ready to make a tangible impact on drug design and manufacturing efficiency. Day-to-Day Responsibilities Design and optimize small molecule formulations using quality-by-design (QbD) principles, with particular expertise in addressing solubility challenges through amorphous solid dispersions, lipid-based systems, and nanoformulation technologies. Define quality targets, identify critical material attributes and process parameters, and conduct systematic risk assessments to guide formulation and manufacturing strategy. Oversee manufacturing scale-up activities and troubleshoot production deviations, employing root cause analysis and corrective action protocols to ensure consistency across laboratory, pilot, and commercial scales. Lead late-stage development initiatives, including clinical supply production, process validation activities, and continued process monitoring through commercialization. Author and evaluate chemical, manufacturing, and control (CMC) sections of regulatory filings; interface directly with regulatory agencies on behalf of development programs. Manage vendor relationships with contract manufacturing partners, maintaining technical oversight, governance protocols, and accountability for timelines, quality, and budget. Mentor and develop a team of scientists and technical staff, providing guidance, professional growth opportunities, and scientific leadership across multiple concurrent programs. Collaborate across analytical development, clinical operations, regulatory, quality, supply chain, and commercial functions to align development strategy with business objectives. What You Bring A Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, Chemistry, or equivalent discipline, combined with 12+ years of progressive pharmaceutical development experience in biotech, pharmaceutical, or CDMO environments. Expert-level knowledge of QbD methodologies: Quality Target Product Profile (QTPP) definition, Critical Quality Attributes (CQAs) identification, design of experiments, design space development, and control strategy frameworks. Proven expertise in small…
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