Director, DMPK

Assembly Biosciences, Inc. is hiring a Director, DMPK in South San Francisco, San Mateo County, to drive the science behind small molecule drug discovery and development. If you thrive at the intersection of pharmacokinetics, lead optimization, and translational research, this on-site role offers a chance to shape programs from discovery through the clinic.

About the Role

As Director, DMPK at Assembly Biosciences, you will serve as a senior subject-matter expert in drug metabolism and pharmacokinetics, partnering with discovery research teams to advance small molecule candidates. Reporting to the Executive Director, DMPK, this full-time, exempt position is based on-site in South San Francisco, California, and centers on guiding lead optimization across preclinical and clinical drug development.

Key Responsibilities

• Apply deep DMPK expertise to support small molecule lead optimization within discovery research programs.
• Inform decision-making across the pipeline, from early discovery through preclinical and clinical stages.
• Collaborate with cross-functional research teams to translate pharmacokinetic and metabolism insights into program strategy.
• Contribute creative, scientifically rigorous solutions that move drug candidates forward.

Qualifications

• Substantial industry research experience in DMPK, with a focus on small molecule programs.
• Demonstrated background supporting lead optimization for discovery research initiatives.
• Familiarity with the full arc of drug development, spanning preclinical and clinical phases.
• A motivated, inventive approach to solving complex pharmacokinetic and metabolism challenges.
• Willingness to work on-site in South San Francisco, San Mateo County (this role is not remote).

About Assembly Biosciences, Inc.

Assembly Biosciences, Inc. is a biotechnology company headquartered in South San Francisco, California, where scientific teams pursue novel small molecule therapies from the earliest stages of discovery through clinical development. The Director, DMPK joins a research-driven environment built around innovation and collaboration.

How to Apply

Ready to advance your career as a Director, DMPK with Assembly Biosciences in South San Francisco? View the full listing and submit your application to be considered for this opportunity.